Diagram of the Day

July 1, 2010

In case you ever need it, here’s a sort of workflow diagram for refurbishing a lung and transplanting it into a rat:

Via Ed Yong, who writes:

In a lab at Yale University, a rat inhales. Every breath this rodent takes is a sign of important medical advances looming on the horizon, for only one of its lungs comes from the pair it was born with. The other was built in a laboratory.

This transplanted lung is the work of Thomas Petersen and a large team of US scientists. Their technique isn’t a way of growing a lung from scratch. Instead it takes an existing lung, strips away all the cells and blood vessels to leave behind a scaffold of connective tissues, and re-grows the missing cells in a vat. It’s the medical equivalent of stripping a house down to a frame of beams and struts and rebuilding the rest from scratch. The whole process only took a few days and when the reconstituted lung was transplanted into a rat, it worked.

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